Cardinals vs. Rams odds, prediction for NFL wild-card playoff game

When the Cardinals face the Rams to finish the wild-card round of the 2021-2022 NFL playoffs on “Monday Night Football” (8:15 p.m. ET, ESPN and ESPN2), they will play the rubber match as NFC West division rivals.

The Rams (12-5) won the West and earned the right to host this game as the No. 4 seed, while the Cardinals (11-6) finished as the No. 5 seed and first wild card in the NFC. Both teams lost in Week 18, but the Rams (at Baltimore) and Cardinals (at Dallas) had big wins in Week 17.

Quarterbacks Kyler Murray and Matthew Stafford started out as MVP candidates, but turnovers and key injuries to the receiving corps caused them to fade down the stretch. Who will emerge and advance to the divisional playoffs?

Here’s everything you need to know to bet on Cardinals vs. Rams in the 2022 NFL playoffs, including updated odds, trends and our expert’s prediction for the wild card game.

Cardinals vs. Rams odds for NFL playoff game

  • Spread: Rams by 4
  • Over/under: 49.5
  • Moneyine: Cardinals +168, Rams -200

The number has been just over a field goal for the Rams for the third matchup of the season. This is due to home-field advantage and a bit more upside due to prime time. The total has been limited due to offensive miscues by both teams of late.